Adding a certain compound to certain chemical reactions, such as: 88511-27-7, 4-Amino-3-iodopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 4-Amino-3-iodopyridine, blongs to pyridine-derivatives compound. Safety of 4-Amino-3-iodopyridine
Example 3; 8-Eth l-6,7,8,9-tetrahydro-5H-pyrido[4,3-b]indoleSi(OEt) (284 mg, 1 .36 mmol) was added to a solution of 4-amino-3-iodopyridine (300 mg, 1 .36 mmol), 4-ethylcyclohexanone (344 mg, 2.72 mmol) and PPTS (68 mg, 0.27 mmol) in pyridine (3 ml). The mixture was flushed with N2 and heated at 160C under microwave for 45 min. Pd(PPh3) (78 mg, 0.068 mmol) and dicyclohexylmethylamine (319 mg, 1 .63 mmol) were added to the reaction mixture. The mixture was flushed with N2, then heated at 170C under microwave for 2 hours. The reaction mixture was cooled and partitioned between H2O and EtOAc. The organic phase was washed with brine, dried over Na2SO4 and concentrated. The residue was subjected to chromatography (silica gel treated with Et3N in DCM, eluting with MeOH in DCM) to afford 220 mg of impure product, which was purified again with HPLC (Ci8, eluting with 10-100% CH3CN in H2O with 0.1 % TFA). 142 mg of gel was obtained from pure fractions. The gel was treated with MeOH and concentrated to give the title compound as a white crystalline solid (142 mg, TFA salt, 33%, hygroscopic).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,88511-27-7, 4-Amino-3-iodopyridine, and friends who are interested can also refer to it.
Reference:
Patent; SANOFI; GROSS, Alexandre; LI, Ronghua; MAJID, Tahir Nadeem; MOORCROFT, Neil David; YU, Kin T.; ZILBERSTEIN, Asher; WO2011/84439; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem