Related Products of 89667-15-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 89667-15-2 as follows.
A round bottom flask was charged with di(pyridin-3-yl)methanol (600 mg, 3.22 mmol) and CH2CI2 (50 mL). Thionyl chloride (353 mu, 4.83 mmol) was added and the reaction was stirred for 18 h at room temperature. The solution was concentrated under reduced pressure. The residue was chromatographed on a silica gel column (100% CH2CI2 to 5% 2 M NH3 in MeOH) and yielded 3,3′-(chloromethylene)dipyridine (415 mg, 64%). XH NMR 400 MHz (CDC13) delta 8.66 (d, J= 2.4 Hz, 2H), 8.59 (dd, J= 4.7, 1.6 Hz, 2H), 7.76 (m, 2H), 7.34 (m, 2H), 6.17 (s, 1H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,89667-15-2, its application will become more common.
Reference:
Patent; ABIDE THERAPEUTICS; THE SCRIPPS RESEARCH INSTITUTE; CISAR, Justin, S.; GRICE, Chery, A.; JONES, Todd, K.; NIPHAKIS, Micah, J.; CHANG, Jae, Won; LUM, Kenneth, M.; CRAVATT, Benjamin, F.; WO2013/103973; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem