Analyzing the synthesis route of 945954-94-9

At the same time, in my other blogs, there are other synthetic methods of this type of compound,945954-94-9, Methyl 6-bromo-3-methoxypicolinate, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.945954-94-9, name is Methyl 6-bromo-3-methoxypicolinate, molecular formula is C8H8BrNO3, molecular weight is 246.06, as common compound, the synthetic route is as follows.HPLC of Formula: C8H8BrNO3

(step .4); To a solution of the compound obtained in step 3 (7.56 g) in THF (110 mL) was added diisobutylaluminum hydride (DIBAL-H) ( 1.5M toluene solution, 24.6 mL) at -78C, and the mixture was stirred at -78C for 1 hr. To the reaction mixture was added saturated aqueous Rochelle salt, and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate and concentrated. The residue was purified by silica gel column chromatography (solvent gradient; 0->33% ethyl acetate/hexane) and crystallized from ethyl acetate/hexane to give 6-bromo-3-methoxypyridine-2- carbaldehyde (5.36 g, 81%) as white crystals,

At the same time, in my other blogs, there are other synthetic methods of this type of compound,945954-94-9, Methyl 6-bromo-3-methoxypicolinate, and friends who are interested can also refer to it.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2007/89031; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem