Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 956010-87-0, name is 3-(Trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 3-(Trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine
Compound 12 (500 mg, 2.67 mmol) was suspended in aqueous ammonia solution (33 %, 10 mL). The mixture was heated in a sealed tube in the microwave oven to 140 C for 10 min. Volatiles were evaporated. To the residue was added ethyl acetate (100 mL) and tert-butyl methyl ether (25mL), and the mixture was heated to 70 C. The hot mixture was filtered, and the residue was washed with tert-butyl methyl ether. The combined filtrates were evaporated to yield the title compound as slightly yellow residue (389 mg, 90 %), which contained traces of corresponding primary amide. 1H NMR (400MHz, DMSO-d6): delta 7.47 (dd, J=8.2, 4.5Hz, 1H), 8.46 (dd, J=8.2, 1.5Hz, 1H), 8.73 (dd, J=4.5, 1.5Hz, 1H), 15.02 (br s, 1H). 13C NMR (125MHz, DMSO-d6): delta 113.5, 115.5, 116.9, 119.6, 128.7, 150.9, 151.0. HRMS m/z calcd for C7H4N4: 144.0436; found: 144.0430.
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Reference:
Article; Schirok, Hartmut; Griebenow, Nils; Fuerstner, Chantal; Dilmac, Alicia M.; Tetrahedron; vol. 71; 34; (2015); p. 5597 – 5601;,
Pyridine – Wikipedia,
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