Application of 1268521-33-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1268521-33-0, name is 3-Bromo-2-chloro-5-nitropyridin-4-amine. This compound has unique chemical properties. The synthetic route is as follows.
A dried RBF was charged with Na2CO3 (61.7 g, 582 mmol), in water (75 mL) and was stirred until a solution was obtained. THF (750 mL) and EtOH (150 mL) were then added and the solution was sparged with argon during the following additions; 3-bromo-2-chloro-5-nitropyridin-4-amine (49 g, 194 mmol) was charged, and phenylboronic acid (53.5 g, 388 mmol). After 20 min of sparging argon, Pd(PPh3)4 (17.9 g, 15.5 mmol) was charged. The reaction was sealed and was run under argon at 85 C. Once the reaction was deemed complete it was concentrated directly. To the residual was added water, and the mixture extracted with EtOAc. The combined organic fractions were combined, dried with MgSO4 and concentrated. The residual was purified via silica gel column chromatography, eluting with 0-30% EtOAc/Hexane. 2-(4-amino-3-bromo-5-nitropyridin-2-yl)phenol was isolated as a red semi solid (39 g, 65% yield).
According to the analysis of related databases, 1268521-33-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Universal Display Corporation; Layek, Suman; Ji, Zhiqiang; Dyatkin, Alexey Borisovich; Boudreault, Pierre-Luc T.; Tsai, Jui-Yi; (251 pag.)US2019/393431; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem