Reference of 86129-63-7, Adding some certain compound to certain chemical reactions, such as: 86129-63-7, name is Ethyl 2,4-dichloro-6-methyl-3-pyridinecarboxylate,molecular formula is C9H9Cl2NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 86129-63-7.
To a solution of 2- (IH-PYRAZOL-3-YL)-1, 3-THIAZOLE (7.71 g, 1.05 eq) in anh. DMF (61 mL), at 0C, under N2, was added NaH 60% in mineral oil (2.03 g, 1. 05 eq) and the reaction mixture was stirred for 10 min. at 0C and then for 1 hr at room temperature. Intermediate 1 (11.34 g, 48.0 MMOL) was then added as a solution in anh. DMF (35 mL) at 0C and the resulting solution was heated at 110C for 3 hr. The reaction was then quenched with water, extracted with EtOAc, washed with brine, dried over anh. NA2SO4, filtered and concentrated in vacuo. The crude product was purified by flash chromatography (silica gel, cHex/EtOAc 7: 3) to give 7.02 g of the title compound as a white solid. NMR (‘H, CDCl3) : 8 7.91 (d, 1H), 7.91 (d, 1H), 7.41 (d, 1H), 7.31 (s, 1H), 7.18 (d, 1H), 4.50 (q, 2H), 2.78 (s, 3H), 1.25 (t, 3H). MS (M/Z) : 349 [MH] +.
According to the analysis of related databases, 86129-63-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SB PHARMCO PUERTO RICO INC; NEUROCRINE BIOSCIENCES INC; GLAXO GROUP LIMITED; WO2004/62665; (2004); A1;,
Pyridine – Wikipedia,
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