Electric Literature of 850429-51-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 850429-51-5, name is Ethyl 6-amino-5-bromonicotinate. A new synthetic method of this compound is introduced below.
2.41 g of ethyl 2-amino-3-bromo-5-pyridinecarboxylate 3d in 120 mL of methanol and 2.8 g of potassium hydroxide in 40 mL of water are placed in a round-bottomed flask. The mixture is stirred with heating at 60 C. for 3 hours. The methanol is evaporated off. After cooling, 10 mL of 5N hydrochloric acid are added. The precipitate is filtered off to give 2.07 g of 6-amino-5-bromonicotinic acid.LC-MS-DAD-ELSD: 217(+) and 219(+)=(M+H)(+) Rt (min)=1.71
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,850429-51-5, its application will become more common.
Reference:
Patent; SANOFI-AVENTIS; US2011/178053; (2011); A1;,
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