Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 38923-08-9, name is Ethyl 6-nitroimidazo[1,2-a]pyridine-2-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. Safety of Ethyl 6-nitroimidazo[1,2-a]pyridine-2-carboxylate
Ethyl 6-nitroimidazo[l,2-alpha]pyridine-2-carboxylate (1.137 g, 4.83 mmol) and 10% Pd on C (200 mg) were suspended in EtOH (4 mL). The reaction mixture was stirred at room temperature under 1 atm of hydrogen for 18 h. It was filtered through a pad of Celite and the filtrate was concentrated under reduced pressure. The resulting residue was purified by chromatography to afford ethyl 6-aminoimidazo[l ,2-alpha]pyridine-2-carboxylate as a green solid (478 mg, yield: 48%). 1H NMR (400 MHz, CDCl3): delta: 8.026 ( I H, s), 7.571 (2H, m), 6.91 1 (1 H, dd, J = 9.6 Hz, J2 = 2.0 Hz), 4.475 (2H, q, J = 7.2 Hz), 1 .438 (3H, t, J = 7.2 Hz).
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Reference:
Patent; SIRTRIS PHARMACEUTICALS, INC.; WO2008/100423; (2008); A1;,
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