Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1737-93-5, name is 3,5-Dichloro-2,4,6-trifluoropyridine. A new synthetic method of this compound is introduced below., HPLC of Formula: C5Cl2F3N
3,5-Dichloro-2,4,6-trifluoropyridine (2.01 g, 9.95 mmol) was ssolved in tetrahydrofuran (40 mL) and cooled to -78 C. ethylmagnesium chloride (6.2 mL, 12.40 mmol) was added slowly to the cooled solution and stirred for 30 minutes. Gradually allowed to warm to 0 C and monitored by LCMS until disappearance of starting material. Worked up with EtOAc (3x) and aq. saturated NaHCO3. The combined organics were washed with brine, dried over magnesium sulfate, filtered and gently concentrated to afford a volatile yellow oil.
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Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ADAMS, Nicholas David; BENOWITZ, Andrew B.; RUEDA BENEDE, Maria Lourdes; EVANS, Karen Anderson; FOSBENNER, David T.; KING, Bryan Wayne; LI, Mei; MILLER, William Henry; REIF, Alexander Joseph; ROMERIL, Stuart Paul; SCHMIDT, Stanley J.; WIGGALL, Kenneth; (1283 pag.)WO2017/216726; (2017); A1;,
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