Application of 55-22-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 55-22-1, name is Isonicotinic acid. A new synthetic method of this compound is introduced below.
General procedure: A mixture of 1 (166 mg, 0.4 mmol), the corresponding acids RCO2H (0.48 mmol), DMAP(10 mg, 0.08 mmol), and DCC (99 mg, 0.48 mmol) in dry CH2Cl2 (10 ml) was stirred at ambient temperature. When the reaction was completed for 2-3 h according to TLC analysis,the mixture was filtered, and the filtrate was diluted by CH2Cl2 (60 ml). The mixture was washed by 0.1 N HCl (30 ml), saturated Na2CO3 (30 ml) and saturated NaCl (30 ml),dried over anhydrous Na2SO4, concentrated in vacuo, and purified by PTLC to give the pure 4alpha-acyloxypodophyllotoxin derivatives 5a, b, e, f in 84-90% yields. The data for 5a,b, e, f are shown as follows.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,55-22-1, Isonicotinic acid, and friends who are interested can also refer to it.
Reference:
Article; Che, Zhi-Ping; Tian, Yue-E; Liu, Sheng-Ming; Jiang, Jia; Hu, Mei; Chen, Gen-Qiang; Journal of Asian Natural Products Research; vol. 21; 10; (2019); p. 1028 – 1041;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem