Reference of 6937-03-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6937-03-7, name is Methyl 2-aminoisonicotinate, molecular formula is C7H8N2O2, molecular weight is 152.1506, as common compound, the synthetic route is as follows.
26 g of lithiumaluminum hydride was dissolved in 800 mL ofanhydrous THF. A solution of 103 g of methyl ether of2-aminoisonicotinate in 600 mL of anhydrous THFwas added at stirring and the formed slurry was boiledfor 3 h. After cooling water was carefully added, theprecipitate was filtered off and washed with 300 mL ofTHF. The combined filtrates were evaporated, theresidue was crystallized from benzene. Yield 61 g(73percent), mp 80?81.5°. 1H NMR spectrum (DMSO-d6),delta, ppm: 4.36 s (2), 5.19 s (1), 5.78 s (2), 6.40 d(1), 6.46 s (1), 7.81 d (1). 13 NMR spectrum(DMSO-d6), delta, ppm: 62.3, 105.2, 110.3, 147.7, 152.7,160.3. Found, percent: 57.63; 6.32; N 22.68. C6H8N2O.Calculated, percent: C 58.05; H 6.4; N 22.56.
Statistics shows that 6937-03-7 is playing an increasingly important role. we look forward to future research findings about Methyl 2-aminoisonicotinate.
Reference:
Short Survey; Lifshits; Ostapchuk; Brel; Russian Journal of Organic Chemistry; vol. 51; 5; (2015); p. 744 – 745; Zh. Org. Khim.; vol. 51; 5; (2015); p. 759 – 760,2;,
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