Application of 1121-60-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1121-60-4, name is Picolinaldehyde, molecular formula is C6H5NO, molecular weight is 107.11, as common compound, the synthetic route is as follows.
General procedure: Equimolar mixture of pyridine carboxaldehyde deriva-tives (1 mmol) and sodium metabisulphite (1 mmol) in DMF (10 mL) was stirred for 10 to 15 min, followed by the addi-tion of o-phenylene diamine/2-aminothiophenol (1 mmol) into it and refluxed for 3 h. The progress of the reaction was monitored by TLC. After completion, the reaction mixture was poured into crushed ice, precipitates were formed which were collected by filtration to afford compounds 1-27 in good yields. Recrystallization from methanol yielded pure crystals.
The chemical industry reduces the impact on the environment during synthesis 1121-60-4, I believe this compound will play a more active role in future production and life.
Reference:
Article; Khan, Momin; Ahmad, Riaz; Rehman, Gauhar; Gul, Naeem; Shah, Sana; Salar, Uzma; Perveen, Shahnaz; Khan, Khalid Mohammed; Letters in drug design and discovery; vol. 16; 9; (2019); p. 984 – 993;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem