Application of 59942-87-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.59942-87-9, name is Pyrazolo[1,5-a]pyridin-2(1H)-one, molecular formula is C7H6N2O, molecular weight is 134.1353, as common compound, the synthetic route is as follows.
To a solution of pyrazolo[1,5-a]pyridin-2-ol (120 mg, 0.89 mmol) in 4 mL of anhydrous DMF, were added K2CO3 (270 mg, 1.95 mmol), 4-(2-chloroethyl)morpholine hydrochloride (183 mg, 0.98 mmol) and Nal (134 mg, 0.89 mmol) and the mixture heated to 80 ºC for 18 h under nitrogen. The solvent was evaporated under reduced pressure and the residue poured into a mixture of EtOAc and water, to afford after drying and evaporation of organic layers, 112 mg of an oil that was purified by silica gel flash chromatography with EtOAc/MeOH (9:1) as eluent to afford 57 mg of 4-(2-(pyrazolo[1,5-a]pyridin-2-yloxy)ethyl)morpholine. 40 mg (0.43 mmol) of anhydrous oxalic acid in 0.5 mL of acetone were added to a solution of 98 mg of 4-(2-(pyrazolo[1,5-a]pyridin-2-yloxy)ethyl)morpholine base oil in 0.5 mL of acetone.
Statistics shows that 59942-87-9 is playing an increasingly important role. we look forward to future research findings about Pyrazolo[1,5-a]pyridin-2(1H)-one.
Reference:
Patent; Laboratorios del. Dr. Esteve, S.A.; Diaz-Fernandez,Jose-Luis; Cuberes-Altisent,Mª Rosa; EP2631236; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem