Electric Literature of 16133-25-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 16133-25-8, name is Pyridine-3-sulfonyl chloride. A new synthetic method of this compound is introduced below.
In 500m reaction flask, 200ml of acetonitrile was added,5- (2-fluorophenyl) -1H-pyrrole-3-carbonitrile (50 g, 0.27 mol),N, N-diisopropylethylamine (41.6 g 0.32 mol) and4-N, N-dimethylaminopyridine (4.69 g, 38.4 mmol),Stir at room temperature. The temperature of the reaction solution was controlled to be not higher than 30 ¡ã C, and a mixed solution of 3-pyridinesulfonyl chloride (52.5 g, 0.29 mol) in 100 ml of acetonitrile was added dropwise.Dropping completed, 25 ¡ã C for 2 hours, the reaction is completed, 300ml of purified water was added to the reaction solution, the reaction temperature was controlled not higher than 30 ¡ã C, the dropwise addition of concentrated hydrochloric acid to adjust the pH to 4-5, 25 ¡ã C with stirring 2 hours, filtered, washed with a mixture of acetonitrile and water, and the solid was collected and dried under reduced pressure at 50 ¡ã C to give 79.5 g of 5- (2-fluorophenyl) -1- (pyridin-3-ylsulfonyl) 3-Nitrile yield 90 ? 5percent.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16133-25-8, its application will become more common.
Reference:
Patent; Shandong Kangmeile Pharmaceutical Technology Co., Ltd.; Geng Fengluan; Liu Yunfeng; Liu Xiaojun; (8 pag.)CN104860923; (2018); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem