As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19828-20-7, name is 2-Amino-5-acetylpyridine, molecular formula is C7H8N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 2-Amino-5-acetylpyridine
Step A: 2-(6-Aminopyridin-3-yl)-6-chloroquinoline-4-carboxylic acid (27) [00392] A solution of l-(6-aminopyridin-3-yl)ethanone 16, example 8, step A) (1.5 g, 11.0 mmol) in ethanol (10 mL) was added slowly to a solution of 5-chloroindoline-2,3-dione (9) (1.66 g, 9.17mmol) in 6M aqueous KOH (lOmL) at 100C. The reaction was monitored by LCMS until the staring material consumed. Then the reaction mixture was concentrated to remove ethanol, the residue was diluted with water (10 mL), the pH value of the mixture was acidified to 5 by adding 1M aqueous HCl solution. The precipitate was filtered to give the desired product (1.2 g, 44%) as an orange solid. LC-MS: (M + H)+ 300.1
With the rapid development of chemical substances, we look forward to future research findings about 19828-20-7.
Reference:
Patent; NEW YORK UNIVERSITY; UNIVERSITY OF ALBANY; SCHMIDT, Ann, Marie; RAMASAMY, Ravichandran; SHEKHTMAN, Alexander; RAI, Vivek; MANIGRASSO, Michaele, B.; (179 pag.)WO2017/184547; (2017); A1;,
Pyridine – Wikipedia,
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