Adding a certain compound to certain chemical reactions, such as: 39856-50-3, 5-Bromo-2-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 5-Bromo-2-nitropyridine, blongs to pyridine-derivatives compound. Recommanded Product: 5-Bromo-2-nitropyridine
Step A: 1-(6-Nitropyridin-3-yl)piperazine Under a protection of nitrogen, to a solution of piperazine (2.55g, 29.56mmol) and 5-bromo-2-nitro-pyridine (5g, 24.63mmol) in acetonitrile (40mL) were added potassium carbonate (5.11g, 36.95mmol) and tetrabutylamine iodide (636.83mg, 1.72mmol) and it was stirred at 100C for 16 hours. It was immediately filtered at a high temperature, and the filter cake was washed with hot acetonitrile, followed by a precipitating of solid from the filtrate, filtration again. The filter cake was washed with a small portion of cold acetonitrile, then spin-dried to give the title compound. MS-ESI (m/z): 209(M+1). 1H NMR (400MHz, DMSO-d6) delta=8.23 (d, J=3.0 Hz, 1H), 8.13 (d, J=9.3 Hz, 1H), 7.44 (dd, J=3.0, 9.3 Hz, 1H), 3.43-3.38 (m, 4H), 2.87-2.76 (m, 4H).
The synthetic route of 39856-50-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; LIU, Shilan; LIANG, Guibai; WANG, Hongjian; ZHANG, Ming; CHEN, Shuhui; (93 pag.)EP3640247; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem