Analyzing the synthesis route of Reference of 953780-42-2

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 953780-42-2, 5-Fluoro-6-methoxynicotinic acid, other downstream synthetic routes, hurry up and to see.

Reference of 953780-42-2, Adding some certain compound to certain chemical reactions, such as: 953780-42-2, name is 5-Fluoro-6-methoxynicotinic acid,molecular formula is C7H6FNO3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 953780-42-2.

To a dry-ice cooled solution of 5-fluoro-6-methoxynicotinic acid (3.5 g, 20.5 mmol) and Et3N (2.3 g, 22.8 mmol) in dry THF (50ml), was added isobutyl chloroformate (3.1 g, 22.7 mmol) slowly to keep the reaction temperature below -200C. After the mixture was stirred for Ih at the same temperature, to it ice-water was added, and the resulting mixture was extracted with ether, and the combined organic layers were washed with brine, dried over Na2SO4 and concentrated under vacuum to afford 5.5 g of (5-fluoro-6-methoxypyridin-3-yl)carbonyl isobutyl carbonate as a yellow oil (98%). 1H-NMR (400MHz, CDCl3) delta 8.65 (d, J= 2Hz, IH, Ar-H), 7.90 (dd, J1 = 10 Hz, J2= 2 Hz, IH, Ar-H), 4.11 (s, 3H, -OCH3), 3.73(m, 2H, -OCH2), 2.09 (m, IH, – CH), 0.98 (m, 6H, -CH3)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 953780-42-2, 5-Fluoro-6-methoxynicotinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK & CO., INC.; WO2007/120729; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem