Synthetic Route of 1448428-04-3 ,Some common heterocyclic compound, 1448428-04-3, molecular formula is C24H24FN7O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Compound WXBB-16 (740.00 mg, 1.27 mmol, 1.00 eq) (a purity of 76.2%), benzylamine (420.00 mg, 3.92 mmol, 428.57 muL, 3.09 eq), and potassium carbonate (550.00 mg, 3.98 mmol, 3.13 eq) were dissolved in acetonitrile (20.00 mL). Then the reaction was stirred at 90 C. for 48 hours. The reaction solution was added with water (30 mL), and then extracted with dichloromethane (30 mL*3). The organic phases were combined and dried over anhydrous sodium sulfate (15 g). The anhydrous sodium sulfate was filtered off, and the filtrate was dried on a rotary evaporator. The crude product was separated and purified by Prep-HPLC (column: Xtimate C18 150*25 mm*5 mum; mobile phase: [water (0.225% FA)-ACN]; B %: 25%-50%, 11.5 min) to obtain compound WX011-1. MS m/z: 533.2 [M+H]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1448428-04-3, Selonsertib, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; FUJIAN COSUNTER PHARMACEUTICAL CO., LTD.; Wu, Chengde; Yu, Tao; Li, Ning; Chen, Shuhui; US2019/375728; (2019); A1;,
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