Anderson, Wayne K. et al. published their research in Journal of Medicinal Chemistry in 1990 | CAS: 89978-52-9

Ethyl 2-bromoisonicotinate (cas: 89978-52-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. HPLC of Formula: 89978-52-9

Vinylogous carbinolamine tumor inhibitors. 24. Synthesis, chemistry, and antineoplastic activity of α-halopyridinium salts: potential pyridone prodrugs of acylated vinylogous carbinolamine tumor inhibitors. was written by Anderson, Wayne K.;Dean, Dennis C.;Endo, Toshiyasu. And the article was included in Journal of Medicinal Chemistry in 1990.HPLC of Formula: 89978-52-9 This article mentions the following:

A series of 4- and 5-[dihydrobis[[(alkylcarbamoyl)oxy]methyl]pyrrolizinyl]-2-halopyridinium iodides, e.g., I (R = F, Cl), were synthesized. The rates of hydrolysis of the α-halopyridinium salts to the corresponding pyridones and the reactivities of the carbamate moieties were studied as a function of pH, buffer composition, and ionic strength. The 4- and 5-pyrrolizinyl-2-halopyridinium iodides and the corresponding pyridones were evaluated against P388 lymphocytic leukemia in vivo. The α-fluoropyridinium compounds were active but the α-chloro compounds were not. This activity was correlated with the rates of hydrolysis of the α-halopyridinium compounds to the active pyridone. In the experiment, the researchers used many compounds, for example, Ethyl 2-bromoisonicotinate (cas: 89978-52-9HPLC of Formula: 89978-52-9).

Ethyl 2-bromoisonicotinate (cas: 89978-52-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. HPLC of Formula: 89978-52-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem