In 2019,Journal of Biomolecular Structure and Dynamics included an article by Anjomshoa, Marzieh; Torkzadeh-Mahani, Masoud; Sahihi, Mehdi; Rizzoli, Corrado; Ansari, Mehdi; Janczak, Jan; Sherafat Esfahani, Sheila; Ataei, Farangis; Dehkhodaei, Monireh; Amirheidari, Bagher. Synthetic Route of C12H12N2. The article was titled 《Tris-chelated complexes of nickel(II) with bipyridine derivatives: DNA binding and cleavage, BSA binding, molecular docking, and cytotoxicity》. The information in the text is summarized as follows:
Two nickel(II) complexes with substituted bipyridine ligand of the type [Ni(NN)3](ClO4)2, where NN is 4,4′-dimethyl-2,2′-bipyridine (dimethylbpy) () and 4,4′-dimethoxy-2,2′-bipyridine (dimethoxybpy) (), have been synthesized, characterized, and their interaction with DNA and bovine serum albumin (BSA) studied by different phys. methods. X-ray crystal structure of shows a six-coordinate complex in a distorted octahedral geometry. DNA-binding studies of and reveal that both complexes sit in DNA groove and then interact with neighboring nucleotides differently; undergoes a partial intercalation. This is supported by mol.-docking studies, where hydrophobic interactions are apparent between and DNA as compared to hydrogen bonding, hydrophobic, and p-p interactions between and DNA minor groove. Moreover, the two complexes exhibit oxidative cleavage of supercoiled plasmid DNA in the presence of hydrogen peroxide as an activator in the order of >. In terms of interaction with BSA, the results of spectroscopic methods and mol. docking show that binds with BSA only via hydrophobic contacts while interacts through hydrophobic and hydrogen bonding. It has been extensively demonstrated that the nature of the methyl- and methoxy-groups in ligands is a strong determinant of the bioactivity of nickel(II) complexes. This may justify the above differences in biomol. interactions. The experimental process involved the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Synthetic Route of C12H12N2)
4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Synthetic Route of C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.