On November 20, 1997, Ankersen, Michael; Stidsen, Carsten Enggaard; Andersen, Henrik Sune published a patent.HPLC of Formula: 199522-66-2 The title of the patent was Preparation of thioureas and guanidines as somatostatin agonists and antagonists. And the patent contained the following:
The title compounds [I and II; m = 2-6; n = 1-3; p = 1-6; R1, R2 = H, (un)substituted C1-6 alkyl; X = S, O, NH, NC(O)Ph, N(CN); A, B, D = (un)substituted aryl, heteroaryl] and their salts, useful for treating medical disorders related to binding to human somatostatin receptor subtypes, were prepared and formulated. Thus, reaction of N-(4-bromobenzyl)-N-(3-isothiocyanatopropyl)-N-(pyridin-2-yl)amine and 3-(1-triphenylmethylimidazol-4-yl)propylamine in CHCl3 followed by treatment of the triphenylmethyl intermediate with HCl afforded 80% III.2HCl. Compounds I are effective at 0.001-50 mg/kg/day. The experimental process involved the reaction of N1-(5-Bromopyrid-2-yl)ethane-1,2-diamine(cas: 199522-66-2).HPLC of Formula: 199522-66-2
The Article related to somatostatin agonist antagonist thiourea guanidine preparation, thiourea preparation formulation somatostatin agonist antagonist, guanidine preparation formulation somatostatin agonist antagonist and other aspects.HPLC of Formula: 199522-66-2