Annamalai, Murali published the artcileHighly stereoselective synthesis of a compound collection based on the bicyclic scaffolds of natural products, Name: 2-Methoxynicotinaldehyde, the main research area is bicyclic compound diastereoselective preparation lipophilicity; Aza-heterocycles; European Lead Factory; drug discovery; natural products; scaffolds.
A natural product inspired synthesis of six different chemotypes and their derivatives for drug discovery research was reported. These bicyclic hetero- and carbocyclic scaffolds are highly novel, rich in sp3 features and with ideal physicochem. properties to display drug likeness. The functional groups on the scaffolds were exploited further to generate corresponding compound collections. Synthesis of two of these collections exemplified with ca. 350 compounds are each also presented. The whole compound library is being exposed to various biol. screenings within the European Lead Factory consortium.
Molecules published new progress about Diastereoselective synthesis. 71255-09-9 belongs to class pyridine-derivatives, name is 2-Methoxynicotinaldehyde, and the molecular formula is C7H7NO2, Name: 2-Methoxynicotinaldehyde.