Safety of 4-AcetylpyridineIn 2021 ,《Chiral Iron(II)-Catalysts within Valinol-Grafted Metal-Organic Frameworks for Enantioselective Reduction of Ketones》 appeared in ACS Catalysis. The author of the article were Antil, Neha; Akhtar, Naved; Newar, Rajashree; Begum, Wahida; Kumar, Ajay; Chauhan, Manav; Manna, Kuntal. The article conveys some information:
The development of highly efficient and enantioselective heterogeneous catalysts based on earth-abundant elements and inexpensive chiral ligands is essential for environment-friendly and economical production of optically active compounds The authors report a strategy of synthesizing chiral amino alc.-functionalized metal-organic frameworks (MOFs) to afford highly enantioselective single-site base-metal catalysts for asym. organic transformations. The chiral MOFs (vol-UiO) were prepared by grafting of chiral amino alc. such as L-valinol within the pores of aldehyde-functionalized UiO-MOFs via formation of imine linkages. The metalation of vol-UiO with FeCl2 in THF gives amino alc. coordinated octahedral FeII species of vol-FeCl(THF)3 within the MOFs as determined by x-ray absorption spectroscopy. Upon activation with LiCH2SiMe3, vol-UiO-Fe catalyzed hydrosilylation and hydroboration of a range of aliphatic and aromatic carbonyls to afford the corresponding chiral alcs. with enantiomeric excesses up to 99%. Vol-UiO-Fe catalysts have high turnover numbers of up to 15,000 and could be reused at least 10 times without any loss of activity and enantioselectivity. The spectroscopic, kinetic, and computational studies suggest iron-hydride as the catalytic species, which undergoes enantioselective 1,2-insertion of carbonyl to give an iron-alkoxide intermediate. The subsequent σ-bond metathesis between Fe-O bond and Si-H bond of silane produces chiral silyl ether. This work highlights the importance of MOFs as the tunable mol. material for designing chiral solid catalysts based on inexpensive natural feedstocks such as chiral amino acids and base-metals for asym. organic transformations. In the experiment, the researchers used 4-Acetylpyridine(cas: 1122-54-9Safety of 4-Acetylpyridine)
4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Safety of 4-Acetylpyridine