In 2009,Aoyagi, Yutaka; Adachi, Yoshiyuki; Akagi, Shunta; Ohno, Naohito; Takeya, Koichi published 《First asymmetric synthesis of CJ-14877 and its enantiomer and their interleukin-1β inhibitory activities》.Bioorganic & Medicinal Chemistry Letters published the findings.Electric Literature of C7H6BrNO2 The information in the text is summarized as follows:
A potent antiinflammatory Me picolinate alkaloid CJ-14877 [(+)-I] and its enantiomer (-)-II were synthesized in two steps starting from com. available Me 5-bromopicolinate. The synthesis includes microwave-assisted Suzuki coupling reaction and Sharpless asym. dihydroxylation. In the experiment, the researchers used many compounds, for example, Methyl 5-bromopicolinate(cas: 29682-15-3Electric Literature of C7H6BrNO2)
Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Electric Literature of C7H6BrNO2