Adding a certain compound to certain chemical reactions, such as: 10201-73-7, 2-Amino-4-methoxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-Amino-4-methoxypyridine, blongs to pyridine-derivatives compound. Safety of 2-Amino-4-methoxypyridine
(41c). A mixture of 2-amino-4-methoxypyridine (2.4 g, 19 mol)and N-bromosuccinimide (3.1 g, 17 mmol) was dissolved in aceticacid (6 mL) and stirred at room temperature for 1 h. The reactionmixture was concentrated under vacuum, basified with saturatedaqueous K2CO3 and extracted with EtOAc. The combined organicswere dried, concentrated under vacuum, and purified by silicagel column chromatography, eluting with 50:1 CH2Cl2:MeOH, togive 41c (1.85 g, 47%). LCMS 203 [M+H]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,10201-73-7, 2-Amino-4-methoxypyridine, and friends who are interested can also refer to it.
Reference:
Article; Cloudsdale, Ian S.; Dickson, John K.; Barta, Thomas E.; Grella, Brian S.; Smith, Emilie D.; Kulp, John L.; Guarnieri, Frank; Kulp, John L.; Bioorganic and Medicinal Chemistry; vol. 25; 15; (2017); p. 3947 – 3963;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem