Related Products of 108118-69-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.108118-69-0, name is 2,6-Difluoropyridin-3-amine, molecular formula is C5H4F2N2, molecular weight is 130.0955, as common compound, the synthetic route is as follows.
Synthesis of N-(2,6-difluoropyridin-3-yl)formamide Acetic anhydride (6 ml) was added to formic acid (6 ml), followed by stirring at room temperature for 20 minutes. Then, a solution of 2,6-difluoro-3-aminopyridine (2.06 g) in tert-butyl methyl ether (7 ml) was added so that the reaction solution was maintained at room temperature. The reaction solution was further stirred at room temperature for four hours. Ethyl acetate and a saturated sodium bicarbonate solution were added to the reaction solution, and the organic layer was separated. The resulting organic layer was washed with brine and then dried over anhydrous sodium sulfate. The drying agent was separated by filtration, and then the organic layer was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to obtain the title compound (2.42 g). The property values of the compound are as follows. 1H-NMR (CDCl3) delta (ppm): 6.86 (dd, J=8.8, 2.8Hz, 1H), 7.42 (brs, 1H), 8.49 (s, 1H), 8.83-8.90 (m, 1H).
The chemical industry reduces the impact on the environment during synthesis 108118-69-0, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Eisai R&D Management Co., Ltd.; EP2181992; (2010); A1;,
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