In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 116026-95-0, name is tert-Butyl (4-formylpyridin-3-yl)carbamate, the common compound, a new synthetic route is introduced below. Application In Synthesis of tert-Butyl (4-formylpyridin-3-yl)carbamate
Sodium triacetoxyborohydride (0.57 g, 2.70 mmol) and acetic acid (0.41, 6.75 mmol) were added to a solution OF N-BOC-3-AMINO-4-PYRIDINE carboxaldehyde (0.50 g, 2.25 mmol) and ETHYL 4-AMINOPIPERIDINE-1-CARBOXYLATE (0.47 g, 2.70 mmol) in dichloroethane (5 rriL) at room temperature. The reaction was stirred overnight, and quenched with saturated aqueous sodium bicarbonate. This was separated, extracted with ethyl acetate and the combined organics were dried over sodium sulfate. The solution was filtered and evaporated to give the crude product. This was purified by chromatography (silica GEL, 1 to 12% methanol in methylene chloride gradient elution), which gave the title compound (0.47 g). MS 379.3.
The synthetic route of 116026-95-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK & CO., INC.; WO2004/92166; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem