The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 117519-09-2, name is 3-Amino-2-chloro-6-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. 117519-09-2
Example 117 [5-TRIFLUOROMETHYL-2- [4- (3-TRIFLUOROMETHYL-PYRIDIN-2-YL)-PIPERAZIN-1-YL]-LH-] imidazo [4,5-b] pyridine, trifluoroacetic acid salt. (a) [N2-(4-METHOXY-BENZYL)-6-TRIFLUOROMETHYL-PYNDINE-2,] 3-diamine. A mixture of the [3-AMINO-2-CHLORO-6- (TRIFLUOROMETHYL)] pyridine (416 mg, 2.1 mmol, Matrix), 4-methoxy-benzylamine (294 mg, 2.1 mmol, Aldrich) and sodium bicarbonate (265 mg, 3.2 mmol) in isoamyl alcohol (0.6 mL) was heated at [220 C] in a microwave synthesizer for 30 min. The reaction mixture was then cooled to room temperature, diluted with MeOH (5 mL), filtered and the filtrate was evaporated in vacuo. The residue was purified by preparative HPLC (gradient 0.1% trifluoroacetic acid in acetonitrile) to give the title compound as a yellow oil. MS (ESI, pos. ion) [M/Z] : 298 [(M+1)]
Statistics shows that 117519-09-2 is playing an increasingly important role. we look forward to future research findings about 3-Amino-2-chloro-6-(trifluoromethyl)pyridine.
Reference:
Patent; AMGEN INC.; WO2004/35549; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem