Synthetic Route of 1254473-66-9, Adding some certain compound to certain chemical reactions, such as: 1254473-66-9, name is 1-(3,5-Dichloropyridin-4-yl)ethanol,molecular formula is C7H7Cl2NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1254473-66-9.
MsCl (32g, 0.28mol) was added in batches to a solution of a mixture of Example 1E (36g, 0.91mol) and triethylamine (21g, 0.21mol) in dichloromethane (1 L) at 0C. The reaction was stirred at 0C for 3 hours and thenquenched with water (100mL) in an ice bath and stirred for 1 hour. After layering, the organic phase was washed withsaturated sodium bicarbonate solution (200mL 3 3) and brine (200mL), then dried over anhydrous sodium sulfate,filtered and the filtrate was concentrated to give a residue that was purified by flash silica gel column chromatographyto give the title compound (pale yellow, 50g, yield 98%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1254473-66-9, 1-(3,5-Dichloropyridin-4-yl)ethanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Harbin Zhenbao Pharmaceutical Co., Ltd.; Medshine Discovery Inc.; CHEN, Shuhui; CHEN, Zhengxia; DAI, Meibi; XIE, Cheng; LI, Peng; ZHANG, Yang; LIANG, Guibai; WANG, Qiang; LIAO, Jiangpeng; SUN, Fei; HU, Guoping; LI, Jian; (166 pag.)EP3333157; (2018); A1;,
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