Electric Literature of 133081-25-1 ,Some common heterocyclic compound, 133081-25-1, molecular formula is C11H15N3O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A mixture of 2-chloro-4,6-dimethyl-1,3,5-triazine (CDMT) (1.76 g, 10 mmol), 2 (2.53 g, 10 mmol) in THF (10 ml), and N-methylmorpholine (1.1 ml, 10 mmol) and after 4 h 4b (2.83 g, 10 mmol) in THF were combined as above to afford 5b as yellow solid. Compound 5b: mp 188-190 C; yield 38%; IR (KBr) nu (cm-1): 1522.0, 1636.2, 1717.8, 2862.6, 2934.4, 3242.6; 1H NMR (CD3OD) (delta ppm): 8.4 (2H, d, J = 8.1 Hz, ArH), 7.7-7.9 (2H, m, ArH), 7.6 (1H, d, J = 5.8 Hz, CCHC), 7.5 (1H, t, J = 5.7 Hz, ArH), 6.6 (1H, d, J = 8.7 Hz, CCHC), 4.6 (2H, s, NH), 3.9-4.0 (2H, m, NHCH2), 3.7 (1H, m, NH), 3.3-3.4 (2H, m, CH2N), 3.0 (2H, m, CH2), 2.7 (2H, m, CH2), 2.5 (1H, m, NH), 1.8-2.0 (8H, m, CH2), 1.7 (2H, m, CH2), 1.4-1.5 (9H, m, BOC); MS (FAB) m/z (M + 1) 519.4, 419.3, 199.1; MS-HR (FAB) Calcd for C28H38N6O3: 518.30054. Found: 519.30688 (M + 1).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,133081-25-1, its application will become more common.
Reference:
Article; Szymanski, Pawel; Markowicz, Magdalena; Mikiciuk-Olasik, Elbieta; Bioorganic Chemistry; vol. 39; 4; (2011); p. 138 – 142;,
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