152460-10-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 152460-10-1, name is N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine, the common compound, a new synthetic route is introduced below.
General procedure: The imatinib analogs 3,4-R1,R2-N-(4-methyl-3(4-(pyridine-3-yl)pyrimidin-2-ylamino)phenyl)benzamide (R1 = R2 = H (1); R1 = H, R2 = SCH3 (2); R1 = NO2, R2 = H (3); R1 = NH2, R2 = H (4); R1 = R2 = NO (5)) and N-(4-methyl-3-(4-(pyridin-3-yl) pyrimidin-2-ylamino)phenyl)picolinamide (6) was synthesized following a modified procedure described in the literature16 as shown in Scheme 1. Briefly, an excess amount of benzoyl chloride compound 1b, 2b, 3b, 4b, 5b or 6b was added to a suspension of 6-methyl-N-(4-(pyridin-3-yl)pyrimidin-2-yl) benzene-1,3-diamine (0.5 g, 2 mmol) in dichloromethane (10 mL) containing TEA (0.58 mL, 4 mmol), and the mixture was reacted at 0 C for 4 h, and TLC of reaction mass indicated the absence of starting compound. The solution was then filtered and washed with dichloromethane, the excess dichloromethane was removed in vacuo, and the residue was purified by recrystallization from ethanol.
Statistics shows that 152460-10-1 is playing an increasingly important role. we look forward to future research findings about N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine.
Reference:
Article; Lue, Shuang; Luo, Qun; Hao, Xiang; Li, Xianchan; Ji, Liyun; Zheng, Wei; Wang, Fuyi; Bioorganic and Medicinal Chemistry Letters; vol. 21; 23; (2011); p. 6964 – 6968;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem