As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16135-36-7, name is Methyl 4-aminonicotinate, molecular formula is C7H8N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C7H8N2O2
To a stirring suspension of methyl 4-aminopyridine-3- carboxylate (0.10 g, 0.659 mmol) in dichloromethane(1 mL) was added a solution of4-tert-butyl-2- (1-Boc-piperidin-4- yloxy) benzoyl chloride (1.3 mmol) in dichloromethane (6 mL), followed byN, N-diisopropylethylamine (0.15 mL, 0.8 mmol) and 4-N, N-dimethylaminopyridine (0. 0084 g, 0.068 mmol). After stirring overnight, the solution was diluted with ethyl acetate and washed three times with satd aqNaHCO3. The combined aq phase was back extracted with ethyl acetate and the combined organic phase was dried withMgSO4, filtered and concentrated in vacuo. The residue was chromatographed over silica gel, eluting with a gradient of 30% ethyl acetate in hexanes through 100% ethyl acetate. The product containing fractions were combined and concentrated in vacuo to give the title compound (0.223 g, 66%) as a thick yellow syrup. 1NMR IS-MS, m/e 512.3(m+1)
With the rapid development of chemical substances, we look forward to future research findings about 16135-36-7.
Reference:
Patent; ELI LILLY AND COMPANY; WO2005/49604; (2005); A2;,
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