With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1824-81-3, name is 2-Amino-6-picoline, molecular formula is C6H8N2, molecular weight is 108.14, as common compound, the synthetic route is as follows.HPLC of Formula: C6H8N2
Step 1 Synthesis of 2,2-dimethyl-N-(6-methyl-2-pyridinyl)propaneamide (21-1) 2-amino-6-picoline (26 g) was dissolved in dichloromethane (280 ml) and the reactor was cooled to 0 C., followed by adding triethylamine (30. g) thereto. To the obtained solution was slowly added dropwise a solution of trimethylacetylchloride (31.8 g) in dichloromethane (20 ml) and the mixture was stirred at room temperature for 3 hours. The resulting mixture was filtered, washed with water, dried over anhydrous magnesium sulfate, concentrated under reduced pressure and then crystallized (dichloromethane/petroleum ether) to yield a pale yellow solid (38 g, 82%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1824-81-3, 2-Amino-6-picoline, and friends who are interested can also refer to it.
Reference:
Patent; Suh, Young Ger; Oh, Uh Taek; Kim, Hee Doo; Lee, Jee Woo; Park, Hyeung Geun; Park, Ok Hui; Lee, Yong Sil; Park, Young Ho; Joo, Yung Hyup; Choi, Jin Kyu; Lim, Kyung Min; Kim, Sun Young; Kim, Jin Kwan; Koh, Hyun Ju; Moh, Joo Hyun; Jeong, Yeon Su; Yi, Jung Bum; Oh, Young Im; US2003/153596; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem