In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 195140-86-4, name is 6-Isopropoxynicotinonitrile, the common compound, a new synthetic route is introduced below. Formula: C9H10N2O
Example 93 2-[6-Isopropoxy-3-pyridyl]-4H-1,3-benzothiazine-4-one A mixture of methyl thiosalicylate (1.85 g, 11.0 mmol), 2-isopropoxy-5-cyanopyridine (1.62 g, 10.0 mmol), triethylamine (1.80 ml, 12.9 mmol) and toluene (10 ml) was refluxed under nitrogen atmosphere for 30 hrs.. The reaction mixture was concentrated.. The residue was subjected to a silica gel column chromatography, eluted with ethyl acetate-hexane (2:1, v/v) and recrystallized from ethyl acetate-isopropylether to give the titled compound (0.89 g, 30 %). mp. 109.7-110.4 C IR (KBr): 1663, 1595, 1570, 1522, 1487, 1381, 1285, 1238, 1096, 1063, 1030, 947, 922, 837, 745 cm-1.1H-NMR (CDCl3) delta: 1.37 (3H, s), 1.39 (3H, s), 5.38-5.47 (1H, m), 6.78 (1H, d), 7.43 (3H, m), 8.38 (1H, dd, J = 2.5, 8. 8 Hz), 8.52 (1H, d, J = 7.6 Hz), 8.96 (1H, d, J = 2.5 Hz).
The synthetic route of 195140-86-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Takeda Chemical Industries, Ltd.; EP1424336; (2004); A1;,
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