Electric Literature of 130473-27-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 130473-27-7, name is 1H-Pyrrolo[2,3-c]pyridine-5-carboxylic acid, molecular formula is C8H6N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a stirred solution of ethyl 1 H-pyrrolo [2,3-c] PYRIDINE-5-CARBOXYLATE [prepared according to M. Dekhane, P. Potier, R. H. Dodd, Tetrahedron, 1993,49, 8139-8146] (0.50 G, 2.63 MMOL) in DMF (10 mL) under a nitrogen atmosphere was added sodium hydride (0.087 g, 80% in mineral oil, 2.89 mmol) and 2, 4-difluorobenzyl bromide (0. 60g, 2.89 mmol). The resulting mixture was stirred for 16 hours at ambient temperature. It was quenched with water (30 ML}, and extracted with ethyl acetate (3 x 30 mL). The combined organic extracts were washed with water (2 x 30 mL), dried over sodium sulfate, concentrated in vacuo and purified by flash chromatography. Elution with hexane: ethyl acetate (1: 1) provided the title compound as a light yellow solid (0.40 g, 48% YIELD). 1 H NMR (CD3OD) #; 8.86 (s, 1 H), 8.47 (s, 1 H), 7.71 (d, 1 H, J = 3. 2Hz), 7.31 (dd, 1 H, J = 6. 3Hz), 6.94-7. 05 (m, 2H), 6.79 (d, 1 H, J = 3.2Hz), 5.63 (s, 2H), 4.46 (q, 2H, J = 7.3Hz), 1.45 (t, 3H, J = 7.3Hz). LCMS (API-ES, M+H+) : 317.0.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 130473-27-7, 1H-Pyrrolo[2,3-c]pyridine-5-carboxylic acid.
Reference:
Patent; PFIZER INC.; WO2004/39803; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem