Related Products of 1086381-43-2 ,Some common heterocyclic compound, 1086381-43-2, molecular formula is C8H10BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Step 4: To a vial containing palladium(II) acetate (4.3 mg, 0.019 mmol) and butyldi-1-adamantylphosphine (13.9 mg, 0.039 mmol) was added 1,4-dioxane (300 ul). The vial was evacuated and refilled with Ar (3*). The solution was warmed to 70 C. for 20 minutes. In a separate vial were combined pivalic acid (9.9 mg, 0.097 mmol), cesium fluoride (44 mg, 0.29 mmol), 2-bromo-4-isopropylpyridine (purchased from CombiPhos Catalysts, Inc.) (29 mg, 0.15 mmol), (R)-4-((1-cyclobutylethyl)amino)-7-methyl-3-(4-(trifluoromethyl)benzyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile (40 mg, 0.097 mmol) and 1,4-dioxane (0.5 mL). The mixture was degassed with Ar for 15 minutes, and the catalyst solution was added to the mixture. The resulting mixture was stirred at 130 C. for 3 days. The mixture was cooled to room temperature and concentrated. The residue was dissolved in DCM and purified by silica gel chromatography (0-100% ethyl acetate/hexanes, linear gradient) to give (R)-4-((1-cyclobutylethyl)amino)-2-(4-isopropylpyridin-2-yl)-7-methyl-3-(4-(trifluoromethyl)benzyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile. MS ESI calc’d for C30H31F3N6 [M+H]+ 533. found 533.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1086381-43-2, its application will become more common.
Reference:
Patent; Christopher, Matthew P.; Fradera Llinas, Francesc Xavier; Machacek, Michelle; Martinez, Michelle; Reutershan, Michael Hale; Shizuka, Manami; Sun, Binyuan; Thompson, Christopher Francis; Trotter, B. Wesley; Voss, Matthew E.; Altman, Michael D.; Bogen, Stephane L.; Doll, Ronald J.; US2014/179680; (2014); A1;,
Pyridine – Wikipedia,
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