Synthetic Route of 68470-59-7 ,Some common heterocyclic compound, 68470-59-7, molecular formula is C7H8BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Sodium azide (48 mg, 073 mmo) was added to a soution of 2(bromomethy 6methypyridne (91 mg, 049 mmo) n dry DMFm). (t8 The reaction mixture was irradiated with microwaves 90 00 for 30 mn. After cooing, water was added and the reaction mixture was extracted with Et20. The organic phase was dried over Na2SO4 and the sovent removed to yied the desred product (33 mg, 46%). 1HNMR (300MHz, CDC3), 6 ppm: 758 (t, J = 8 Hz, IH), 7.13(d, J 8 Hz, 1H), 7.08 (d, J = 8Hz, 1H), 4,43 (s, 2H), 2.54 (s, 3H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 68470-59-7, 2-(Bromomethyl)-6-methylpyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; LABORATORIOS DEL DR. ESTEVE, S.A.; CUEVAS CORDOBES, Felix; ALMANSA-ROSALES, Carmen; GARCIA LOPEZ, Monica; WO2015/91939; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem