Adding a certain compound to certain chemical reactions, such as: 17368-12-6, 2-Chloro-4-hydroxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 2-Chloro-4-hydroxypyridine, blongs to pyridine-derivatives compound. name: 2-Chloro-4-hydroxypyridine
A mixture of 2-chloropyridin-4-oi (5 g, 38.7 mmoi), K2C03 (10.7 g, 77.5 mnmol) and iodomethane (10.9 g, 77.5 mmol) in DMF (70 mL) was stirred at RI? for 15 h, diluted with EtOAc (100 mL) and filtered. The filtrate was washed with water, brine, dried over MgSO4 and filtered. The filtrate was concentrated in vacuo to give the crude product, which was purified bychromatography on silica (5-50% EtOAc in petroleum ether) to give the title compound as an oil. LRMS rn/z (M+FI) 144.0 found, 144.0 required.
The synthetic route of 17368-12-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott D.; LIVERTON, Nigel; LUO, Yunfu; SKUDLAREK, Jason; (79 pag.)WO2016/95204; (2016); A1;,
Pyridine – Wikipedia,
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