Synthetic Route of 607373-83-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 607373-83-1, name is 2-Chloro-4-methoxy-5-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows.
2-chloro-4-methoxy-5-nitropyridine (0.6 g, 3.19 mmol), thiophene-2-boronic acid (0.45 g, 3.5 mmol), [l,l ‘-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (0.26 g, 0.32 mmol) and cesium carbonate (1.55 g, 4.8 mmol) in DMF (12 mL) were stirred and heated in a sealed tube at 90C for 18h. The reaction mixture was cooled to room temperature, filtered through Celite and washed through with DCM. The filtrate was washed with water, dried (hydrophobic frit) and concentrated in vacuo. The residue was purified by column chromatography using silica gel and eluting with EtOAc in hexane (0-30%) to give the desired compound.
According to the analysis of related databases, 607373-83-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GALAPAGOS NV; MENET, Christel Jeanne Marie; SCHMITT, Benoit Antoine; GENEY, Raphael Jean Joel; DOYLE, Kevin James; PEACH, Joanne; PALMER, Nicholas John; JONES, Graham Peter; HARDY, David; DUFFY, James Edward Stewart; WO2013/117645; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem