Related Products of 81565-18-6, Adding some certain compound to certain chemical reactions, such as: 81565-18-6, name is 2-Chloro-4-(trifluoromethyl)pyridine,molecular formula is C6H3ClF3N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 81565-18-6.
Intermediate 7 [ 2-R4-(METHVLTHIO) PHENYLL-4-(TRIFLUOROMETHYL)-PYRIDINE] To a mixture of 2-chloro-4- (trifluoromethyl) pyridine (19.9g, [0.] [11MOL),] 4- [(METHYLTHIO) PHENYLBORONIC] acid (21.9g, 0. [13MOL), 1M] aqueous sodium carbonate [(180ML)] and 1,2-dimethoxyethane (270mL) under an atmosphere of nitrogen was added palladium tetrakistriphenylphosphine (3.78g, 3. [3MMOL)] and the reaction heated at [100C] for 14 hours. After cooling and concentration in vacuo, the residue was partitioned between ethyl acetate (350mL) and water (400mL) and separated. The aqueous layer was further extracted with ethyl acetate (2 x [150ML)] and the combined organic layers were dried over sodium sulfate and [CONCENTRATED IN VACUO.] Filtration through a pad of silica gel (200g) eluting with a gradient of ethyl acetate in cyclohexane gave the title compound (29.4g) LC retention time 3.62mins, MS m/z 269 [(MH+).]
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 81565-18-6, 2-Chloro-4-(trifluoromethyl)pyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GLAXO GROUP LIMITED; BESWICK, Paul; MODI, Sandeep; PEGG, Neil; SKIDMORE, John; SWARBRICK, Martin; WO2004/24691; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem