Electric Literature of 6959-47-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6959-47-3, name is 2-(Chloromethyl)pyridine hydrochloride. This compound has unique chemical properties. The synthetic route is as follows.
(2-Chloromethyl)pyridine hydrochloride was dehydrochlorinated by dissolution in an aqueous solution saturated with sodium carbonate and then extracted with dichloromethane. To a 7mL solution of 1,3-diamino-2-propanol (144mg) in acetonitrile was added dropwise a 5mL solution of (2-chloromethyl)pyridine (815mg) in acetonitrile. Then, triethylamine (1.75mL) was added dropwise to the reaction mixture that was then allowed to stir at room temperature for 5 days. After removing the solvent under vacuum, the mixture was dissolved in dichloromethane and washed three times with water. Purification by silica gel column chromatography (CHCl3/CH3OH) yielded 351mg (48%) of the expected product as a pale yellow oil. 1H NMR analysis (CDCl3, 360MHz): delta (ppm): 8.529 (4H, d, JHH=4.7Hz), 7.616 (4H, td, JHH=7.7Hz, JHH=1.8Hz), 7.402 (4H, d, JHH=7.9Hz), 7.152 (4H, td, JHH=4.7Hz, JHH=1.4Hz), 3.935-4.101 (9H, m), 2.72 (4H, m). HR ESI-MS analysis: m/z 455.2551,
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6959-47-3, 2-(Chloromethyl)pyridine hydrochloride.
Reference:
Article; Trehoux, Alexandre; Roux, Yoann; Guillot, Regis; Mahy, Jean-Pierre; Avenier, Frederic; Journal of Molecular Catalysis A: Chemical; vol. 396; (2015); p. 40 – 46;,
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