Synthetic Route of 1049744-89-9 ,Some common heterocyclic compound, 1049744-89-9, molecular formula is C6H7ClF3N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A mixture of 5-(4-methoxyphenyl)-1,2,4-oxadiazole-3-carbaldehyde (500 mg, 2.40 mmol) and2-hydrazino-5-(trifluoromethyl)pyridine hydrochloride(877 mg, 2.52 mmol) in MeCN (10 n) was stirred atRT for 3 h. The resulting suspension was diluted with water (10 mL) and filtered. The filter cake was washed with water (10 mL) and dried overnight invacuum oven (50 C, 20 mbar) to give the title compound as a brown solid (630 mg, 1.73 mmol, 72%,Ca. 90:10 mixture of stereoisomers).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1049744-89-9, its application will become more common.
Reference:
Patent; BAYER CROPSCIENCE AKTIENGESELLSCHAFT; KENNEDY, Jason W. J.; VON MORGENSTERN, Sascha; (37 pag.)WO2016/135062; (2016); A1;,
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