Adding a certain compound to certain chemical reactions, such as: 62674-71-9, 2-Iodo-6-methylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-Iodo-6-methylpyridine, blongs to pyridine-derivatives compound. Safety of 2-Iodo-6-methylpyridine
The title compound was prepared following the procedure reported above for the compound of Example 1 replacing Compound llOa for Compound la and 2-iodo-6-methylpyridine for 3-chlorobenzoyl chloride. After the usual work-up, the reaction crude was purified by automated flash chromatography (SP1® Biotage, 10 g SNAP column) eluting with PE – EtOAc gradient from 9:1 to 6:4 affording the title product as a dense colourless oil (77.8 percent). E/Z mixture 55:45 (1H-NMR).UPLC-MS [M+H]= 353.16, 353.231H NMR (400 MHz, CHLOROFORM-d) mix of isomers oe ppm 7.57 (br s, 2 H), 7.20 – 7.27 (m, 2 H), 7.10 (br d, 2 H), 5.69 (s, 1 H) and 5.62 (s, 1 H), 3.26 – 3.41 (m, 4 H), 2.82 (s, 2 H), 2.59 (br s, 6 H), 2.51 (s, 2 H) and 2.53 (br s,2 H), 2.23 – 2.34 (m, 4 H), 2.21 (m, 2 H) and 1.94 – 2.12 (m, 4 H), 1.62 – 1.81 (m, 4 H), 1.49 (m, 18 H)
At the same time, in my other blogs, there are other synthetic methods of this type of compound,62674-71-9, 2-Iodo-6-methylpyridine, and friends who are interested can also refer to it.
Reference:
Patent; RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA SPA; RIVA, Carlo; GRAZIANI, Davide; LONGHI, Matteo; CALLEGARI, Elisa; FRIGERIO, Fabio; ANGELICO, Patrizia; (197 pag.)WO2019/2571; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem