Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 16179-97-8, name is 2-(Pyridin-2-yl)acetic acid hydrochloride. A new synthetic method of this compound is introduced below., Formula: C7H8ClNO2
To a solution of 2-(pyridin-2-yl)acetic acid hydrochloride salt MMMMMM (50.0 g, 288.0 mmol, 1.0 equiv.) in methanol (500 mL, 0.5M) at 0 C was added thionyl chloride (31.5 mL, 432.0 mmol, 1.5 equiv.) dropwise. The reaction was stirred at 0 C for 60 minutes or until the reaction was determined to be complete by LCMS or TLC. The reaction was carefully quenched with sodium carbonate and the aqueous layer extracted with ethyl acetate. The combined organic layers were washed with water, brine, dried over magnesium sulfate, filtered, and concentrated in vacuo. The resulting product (NNNNNN, 41.5 g, 275.0 mmol, 95%) was used in the next step without further purification.
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Reference:
Patent; EISAI R&D MANAGEMENT CO., LTD.; KEANEY, Gregg F.; WANG, John; GERARD, Baudouin; ARAI, Kenzo; LIU, Xiang; ZHENG, Guo, Zhu; KIRA, Kazunobu; TIVITMAHAISOON, Parcharee; PRAJAPATI, Sudeep; GEARHART, Nicholas C.; KOTAKE, Yoshihiko; NAGAO, Satoshi; KANADA SONABE, Regina, Mikie; MIYANO, Masayuki; MURAI, Norio; BUONAMICI, Silvia; YU, Lihua; PARK, Eunice, Sun; CHAN, Betty; SMITH, Peter, G.; THOMAS, Michael P.; PAZOLLI, Ermira; LIM, Kian, Huat; (54 pag.)WO2017/87667; (2017); A1;,
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