Electric Literature of 180995-12-4, Adding some certain compound to certain chemical reactions, such as: 180995-12-4, name is 2,4-Dichloronicotinonitrile,molecular formula is C6H2Cl2N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 180995-12-4.
(114a) 2-chloro-4-(ethylthio)nicotinonitrile; N,N -dimethylacetamide (1 mL) solution of sodium thioethoxide (93 mg, 1.1 mmol) was added to N,N -dimethylacetamide (1 mL) solution of 2,4-dichloronicotinonitrile (173 mg, 1.00 mmol) which was produced in Example 111 (111a) at 0C and the mixture was stirred at room temperature for one hour. Water (3 mL) was added to the reaction liquid, and generated powder was separated by filtration and further purified by silica gel column chromatography (hexane/ethyl acetate =3:1) and the title compound was obtained (44 mg, yield 22%). Pale yellow powder Mp 97-98C; IR (KBr) numax 2226, 1556, 1518, 1431, 1379, 1199, 819 cm-1; 1H NMR(CDCl3, 500 MHz) delta 1.46 (3H, t, J = 7.3 Hz), 3.12 (2H, q, J = 7.3 Hz), 7.11 (1H, d, J = 5.9 Hz), 8.33 (1H, d, J = 5.9 Hz); HRMS m/z calcd for C8H7N235ClS 198.0018, found 198.0011; MS (EI) m/z: 198 [M+], 183, 170, 165, 147, 134, 126, 108, 98, 76, 69, 64, 46.
According to the analysis of related databases, 180995-12-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Sankyo Company, Limited; EP1764367; (2007); A1;,
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