Electric Literature of 148493-37-2 ,Some common heterocyclic compound, 148493-37-2, molecular formula is C5H2Cl2IN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a degassed solution of iodide (2.0 g, 7.30 mmol), boronic ester (2.70 mL, 7.305 mmol) and 1,1′-bis(di-tert-butylphosphino)ferrocene palladium dichloride (238 mg, 0.365 mmol)was added degassed aq. K3P04 (22 mL, 22.0 mmol, 1M). The reaction mixture was stirred atroom temperature for 16 h. The mixture was concentrated, diluted with EtOAc and the aqueouslayer was cut. The organic layer was dried over Mg2S04 and concentrated to a black oil. Themixture was purified on silica with DCM to obtain (E)-3-(4-((tert-butyldimethylsilyl)oxy)but-1-10 en-1-yl)-2,6-dichloropyridine (2.5 g, 100% yield). MS (M+Ht: 331.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 148493-37-2, 2,6-Dichloro-3-iodopyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK SHARP & DOHME CORP.; DAI, Xing; LIU, Hong; PALANI, Anandan; HE, Shuwen; BROCKUNIER, Linda L.; NARGUND, Ravi; MARCANTONIO, Karen; ZORN, Nicolas; XIAO, Dong; PENG, Xuanjia; LI, Peng; GUO, Tao; WO2014/121416; (2014); A1;,
Pyridine – Wikipedia,
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