Adding a certain compound to certain chemical reactions, such as: 271-29-4, 1H-Pyrrolo[2,3-c]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 271-29-4, blongs to pyridine-derivatives compound. Product Details of 271-29-4
N-Iodosuccinimide (1.05 g, 4.66 mmol, 1.1 eq) was added to a solution of 6-azaindole (0.50 g, 4.24 mmol, 1.0 eq) in acetonitrile (25 mL). The reaction was stirred at room temperature for 1.5 hours before concentrating to remove the solvent. The residue was partitioned between EtOAc (100 mL) and Na2S2O3 (100 mL). The organics were washed with NaHCO3 (80 mL) and brine (80 mL), dried (Na2SO4) and concentrated under reduced pressure. MPLC (silica, 013% MeOH [2M NH3]-CH2Cl2) yielded 3-iodo-6-azaindole as a pink solid. To a solution of 3-iodo-6-azaindole (0.471 g, 1.93 mmol, 1.0 eq) in dimethylformamide (15 mL) at 0C was added sodium hydride (0.93 g of a 60% suspension in oil, 2.32 mmol, 1.2 eq). The reaction was stirred at 0C for 30 minutes and benzenesulfonyl chloride (0.30 mL, 2.32 mmol, 1.2 eq) added. The reaction was stirred between 0C and room temperature for 3 hours. The reaction was partitioned between EtOAc (80 mL) and NaHCO3-water (1:1, 80 mL). The organics were washed with brine (80 mL), water (80 mL) and brine (80 mL), dried (Na2SO4) and concentrated under reduced pressure. MPLC (silica, 4080% EtOAc-hexane) yielded 3-iodo-1-benzenesulfonyl-6-azaindole as a white solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,271-29-4, its application will become more common.
Reference:
Article; Shaw, Simon J.; Goff, Dane A.; Lin, Nan; Singh, Rajinder; Li, Wei; McLaughlin, John; Baltgalvis, Kristen A.; Payan, Donald G.; Kinsella, Todd M.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 11; (2017); p. 2617 – 2621;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem