Adding a certain compound to certain chemical reactions, such as: 105752-11-2, 3-Amino-4-iodopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 3-Amino-4-iodopyridine, blongs to pyridine-derivatives compound. Application In Synthesis of 3-Amino-4-iodopyridine
To a stirred solution of 4-iodopyridin-3-amine (500 mg, 2.2 mmol) in acetonitrile (5 mL) wasadded tert-butyl (2-amino-2-thioethoxyethyl)carbamate (561 mg, 2.9 mmol) and CaO (255 mg,4.5 mmol) at room temperature. The reaction mixture was purged with argon for 15 minutes,then dppf (151 mg, 0.27 mmol) and Pd2(dba)3 (64 mg, 0.06 mmol) was added to the reactionmixture. The reaction mixture was purged with argon for further 5 minutes and stirred in sealedtube at 60 C for 16 h. The reaction mixture was filtered through celite pad and washed the pad
At the same time, in my other blogs, there are other synthetic methods of this type of compound,105752-11-2, 3-Amino-4-iodopyridine, and friends who are interested can also refer to it.
Reference:
Patent; ANTABIO SAS; LEIRIS, Simon; DAVIES, David Thomas; EVERETT, Martin; SPRYNSKI, Nicolas; SUTTON, Jonathan Mark; BODNARCHUK, Michael Steven; PALLIN, Thomas David; CRIDLAND, Andrew Peter; BLENCH, Toby Jonathan; CLARK, David Edward; ELLIOTT, Richard Leonard; (197 pag.)WO2018/172423; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem