Application of 13959-02-9 , The common heterocyclic compound, 13959-02-9, name is 3-Bromoisonicotinic acid, molecular formula is C6H4BrNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: A mixture of theappropriate carboxylic acid (1.38 mmol) and 1,1′-carbonyldiimidazole(0.25 g, 1.52 mmol) in 1,4-dioxane (10 ml)was stirred for 30 min at 80, followed by the addition ofcompound 8l (0.36 g, 1.38 mmol) and stirring for 3 h at100. The substrate conversion was monitored by TLC(eluent CHCl3-MeOH, 7:3). After the reaction wascomplete, the solvent was evaporated under vacuum, and the product was isolated chromatographically (eluting withEtOAc in the case of compounds 9a,b,e, and with CHCl3-MeOH, 10:1 in the case of compounds 9,d).
The synthetic route of 13959-02-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Krolenko, Konstantin Yu.; Vlasov, Sergiy V.; Zhuravel, Irina A.; Chemistry of Heterocyclic Compounds; vol. 52; 10; (2016); p. 823 – 830; Khim. Geterotsikl. Soedin.; vol. 52; 10; (2016); p. 823 – 830,8;,
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