Reference of 86649-57-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 86649-57-2, name is 3-Pyridyloxyacetic acid, molecular formula is C7H7NO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Add O-(7-azabenzotriazol- 1 -yl)-N,N,N?,N?-tetramethyluroniumhexafluorophosphate (584.56 mg, 1.81 mmol) and triethylamine (306.11 mg, 421.63 tL, 3.02 mmol) to a solution of 1-cyclopropyl-N-(1,2,3,4-tetrahydroisoquinolin-6-10 yl)methanesulfonamide (322.30 mg, 1.21 mmol) and 2-(3-pyridyloxy)acetic acid (185.30 mg, 1.21 mmol) in dimethylfomamide (6 mL). Stir the mixture at room temperature for 18 hours. Concentrate under reduced pressure. Pre-purify by an ion exchangechromatography, eluting with 10% methanol/dichloromethane followed by 2 N NH3 inmethanol. Concentrate the latter basic fraction and further purify the crude material by HPLC (XTeffa MS C18 21×100 m) eluting with a mobile phase of 20 mM ammonium carbonate at pH 9 in water/ACN (20% to 40% ACN over 8 minutes at 25 mL/minute) to afford the title compound (203 mg, 0.51 mmol). MS (m/z): 402 (M+1).
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Reference:
Patent; ELI LILLY AND COMPANY; BURKHOLDER, Timothy Paul; DEL PRADO, Miriam Filadelfa; FERNANDEZ, Maria Carmen; HEINZ II, Lawrence Joseph; PRIETO, Lourdes; ZHAO, Genshi; WO2015/54060; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem